Irbesartan Teva, INN-irbesartan
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منابع مشابه
Cost-effectiveness of early irbesartan treatment versus control (standard antihypertensive medications excluding ACE inhibitors, other angiotensin-2 receptor antagonists, and dihydropyridine calcium channel blockers) or late irbesartan treatment in patients with type 2 diabetes, hypertension, and renal disease.
OBJECTIVE The aim of this study was to determine the most cost-effective time point for initiation of irbesartan treatment in hypertensive patients with type 2 diabetes and renal disease. RESEARCH DESIGN AND METHODS This study was a Markov model-simulated progression from microalbuminuria to overt nephropathy, doubling of serum creatinine, end-stage renal disease, and death in hypertensive pa...
متن کاملDesign, Development and In Vitro Characterization of Self Emulsifying Drug Delivery System for Irbesartan
The objectives of present investigations were to optimize concentration of oil, surfactant and cosurfactant by pseudoternary phase diagrams and to develop a stable formulation of self emulsifying drug delivery system (SEDDS) in order to enhance the dissolution rate of poorly soluble Irbesartan (IBS) by SEDDS. Pseudoternary phase diagrams were constructed to identify the self emulsifying region....
متن کاملThe Effects Of Irbesartan on Sympathetic Activity in Humans
In experimental settings, angiotensin II has been reported to interact with the sympathetic nervous system both centrally and peripherally. Direct evidence for this mechanism is limited in humans. We have examined the effect of AT1 receptor blockade on plasma noradrenaline during isometric handgrip exercise in healthy young volunteers. This study investigated the effects of five days pretreatme...
متن کاملRole of cytochrome P-4502C9 in irbesartan oxidation by human liver microsomes.
The oxidative metabolism of irbesartan, a new nonpeptide angiotensin II receptor antagonist, was investigated on 12 human fully characterized hepatic microsomes and purified cytochrome P-450 (CYP) isoforms. After incubation of microsomes with irbesartan and NADPH, four main hydroxy metabolites were formed, as confirmed by liquid chromatography-mass spectrometry analysis. Irbesartan oxidation fo...
متن کاملThe new angiotensin II receptor antagonist, irbesartan: pharmacokinetic and pharmacodynamic considerations.
This article reviews the pharmacokinetics and pharmacodynamics of angiotensin II (AII) receptor antagonists (AIIRA), with particular focus on the novel compound irbesartan. Irbesartan has the highest oral bioavailability in its class (60% to 80%) and, unlike valsartan, its absorption is not affected by food. Irbesartan displays linear, dose related pharmacokinetics and, with the exception of ta...
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